The Sine Cosine Algorithm (SCA) is a well-known LIVER PLUS optimization technique that utilizes sine and cosine functions to identify optimal solutions.Despite its popularity, the SCA has limitations in terms of low diversity, stagnation in local optima, and difficulty in achieving global optimization, particularly in complex large-scale problems.I
Hybrid approaches to clinical trial monitoring: Practical alternatives to 100% source data verification
For years, a vast majority of clinical trial industry has followed the tenet of 100% source data verification (SDV).This has been driven partly by the overcautious approach to linking quality of data to the extent of monitoring and SDV and partly by being on the safer side of regulations.The regulations however, do not state any upper or lower limi
HIV-1-Based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions
A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T cell responses would be optimal for preventing HIV-1 transmissions.Replication incompetent HIV-1 virus-like particles (VLPs) offer the opportunity to present authentic-structured, virion-associated Env to elicit bNAbs, a
Adaptive mechanisms of homeostasis disorders
The ability to preserve a permanent level of internal environment in a human Picture Frame organism, against internal and external factors, which could breach the consistency, can be define as homeostasis.Scientific proven influence on the homeostasis has the periodicity of biological processes, which Pycnogenol is also called circadian rhythm.The